Fluanxol Depot Flupenthixol Injection

About Fluanxol Depot Flupenthixol Injection

FLUANXOL DEPOT is a potent daytime neuroleptic. Fatigue, often observed during treatment with other neuroleptics, and which is particularly troublesome to re-socialized patients, does not occur with FLUANXOL DEPOT. On the contrary, the drug has activating properties which may be beneficial to chronic schizophrenics, who become more open, contact seeking, co-operative and active during treatment. Pharmacokinetic studies on FLUANXOL DEPOT in human volunteers and in patients have shown that FLUANXOL DEPOT injections can be given with intervals of 2-4 weeks. The maximal serum concentration is seen by the end of the first week after injection of FLUANXOL DEPOT in contrast to a peak 3-6 hours after FLUANXOL by mouth. As the drug given parenterally is not metabolized in the liver during absorption FLUANXOL DEPOT can be administered in lower doses than FLUANXOL tablets. Pharmacokinetically a weekly dose of 25 mg FLUANXOL DEPOT is equivalent to a daily oral dose of 10 mg FLUANXOL.

CONTRA-INDICATIONS:

• Extremely excitable and overactive patients.
• Alcohol and opiate poisoning.
• Like other psychotropics, FLUANXOL DEPOT should not be given to pregnant women.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:

• Extrapyramidal symptoms may occur, especially in high dosages, but they have rarely been refractory to anti-Parkinsonian agents. Since the extrapyramidal complications tend to disappear on continued FLUANXOL DEPOT medication, the anti-Parkinsonian agents may often be withdrawn eventually.
• Autonomic side-effects are rare.
• FLUANXOL DEPOT may at times cause insomnia.

PRESENTATION:

• 1 x 1 mL (20 mg/mL)
• 5 x 1 mL (20 mg/mL)
• 1 x 2 mL (40 mg/2 mL)
• 5 x 2 mL (40 mg/2 mL)
• Vial for injection: 1 x 10 mL (20 mg/mL)